Publications

Most of these papers have abstracts that are accessible through PubMed.

Mannitol as a Mucociliary Clearance Agent  

Authors 

Title 

Reference

K De Boeck, E Haarman, J Hull, LC Lands, A Moeller, A Munck, J Riethmüller, H Tiddens, S Volpi, J Leadbetter, B Charlton, A Malfroot, for the DPM-CF-204 Study Group

Inhaled dry powder mannitol in children with cystic fibrosis: a randomised efficacy and safety trial

 Journal of Cystic Fibrosis

Flume PA, Aitken M, Bilton D, Agendt P,
Charlton B,
Forster E, Fox HG, Hebestreit H, Kolbe J, Zuckerman JB, Button

Optimising inhaled mannitol
for cystic fibrosis in an adult population

Breathe. 2015 March v11

DOI: 10.1183/20734735.021414
Hart A, Sugumar K, Milan SJ, Fowler SJ, Crossingham I Inhaled hyperosmolar agents for bronchiectasis (Review) Cochrane Database Syst Rev. 2014 May 12;5:CD002996.
Bilton D, Stanford G. The expanding armamentarium of drugs to aid sputum clearance: how should they be used to optimize care? Curr Opin Pulm Med. 2014 Nov;20(6):601-6
Bilton D, Daviskas E, Anderson SD, Kolbe J, King G, Stirling R, Thompson B, Milne D, Charlton B. A phase III randomised study of the efficacy and safety of inhaled dry powder mannitol (Bronchitol) for the symptomatic treatment of non-cystic fibrosis bronchiectasis. Chest. 2013 Feb 21. doi: 10.1378/chest.12-1763. [Epub ahead of print]
Bilton D, Bellon G, Charlton B, Cooper P, De Boeck K, Flume PA, Fox HG, Gallagher CG, Geller DE, Haarman EG, Hebestreit HU, Kolbe J, Lapey A, Robinson P, Wu J, Zuckerman JB, Aitken ML; For the CF301 and CF302 Investigators. Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis. J Cyst Fibros. 2012 Dec 9. pii: S1569-1993(12)00206-8. doi: 10.1016/j.jcf.2012.11.002. [Epub ahead of print]
Aitken ML, Bellon G, De Boeck K, Flume PA, Fox HG, Geller DE, Haarman EG, Hebetreit HU, Lapey A, Schou IM, Zuckerman JB, Charlton B. Long-term Inhaled Dry Powder Mannitol in Cystic Fibrosis: An International Randomized Study (CF302) Am J Respir Crit Care Med. 2012; 185(6): 645-52. Epub Dec 2011
Bilton D, Robinson P, Cooper P, Gallagher CG, Kolbe J, Fox H, Inhaled dry powder mannitol in cystic fibrosis. An efficacy and safety study. Eur Respir J. 2011 Nov;38(5):1071-1080. Epub 2011 Apr 8
 Jaques A, Charlton B, for the CF301 study investigators.    
Hurt K, Bilton D Inhaled mannitol for the treatment of cystic fibrosis Expert Rev. Respir. Med. 2012; 6(1): 19-26
Pettit RS, Johnson CE. Airway-rehydrating agents for the treatment of cystic fibrosis: past, present, and future Ann Pharmacother. 2011 Jan;45(1):49-59
Teper A, Jaques A, Charlton B.

 

Inhaled mannitol in patients with cystic fibrosis: A randomised open-label dose response trial. J Cyst Fibros. 2011 Jan;10(1):1-8
Tang P, Chan HK, Rajbhandari D, Phipps P. Method to introduce mannitol powder to intubated patients to improve sputum clearance. J Aerosol Med Pulm Drug Deliv. 2011 Feb;24(1):1-9
Daviskas E, Anderson SD, Young IH. Beneficial effect of inhaled mannitol and cough in asthmatics with mucociliary dysfunction Respir Med. 2010 Nov;104(11):1645-53
Anderson SD and Brannan JD.  Mannitol Collecting Sputum (editorial) Clin Exp All 2010; 40: 193-196
Minasian CC, Wallis C, Metcalfe C, Bush A  Comparison of inhaled mannitol, daily rhDNase, and a combination of both in children with cystic fibrosis: a randomised trial Thorax 2010: 65:51-56 Published online 8 Dec 2009
Clinical Study (CF203)
Daviskas E, Anderson SD, Young IH Effect of mannitol and repetitive coughing on the sputum properties in bronchiectasis Respir Med. 2010 Mar;104(3):371-7
Daviskas E, Anderson SD, Jaques A, Charlton B Inhaled Mannitol improves the hydration and surface properties of Sputum in patients with cystic fibrosis Chest 2010; 137(4): 861-868
Jaques A, Daviskas E, Turton JA, McKay K, Cooper P, Stirling RG, Robertson CF, Bye PT, Lesouëf PN, Shadbolt B, Anderson SD, Charlton B Inhaled dry powder mannitol (Bronchitol) improves FEV1 in cystic fibrosis  Chest 2008; 133: 1388-139
Daviskas E, Anderson S.D, Eberl S, Young IH Effect of increasing doses of mannitol on mucus clearance in patients with bronchiectasis  Eur Respir J 2008; 31: 765-772
Daviskas E, Anderson S.D, Young IH Inhaled mannitol changes the sputum properties in asthmatics with mucus hypersecretion Respirology 2007;12(5): 683-91
Minasian CC, Wallis C, Bush A Mannitol as a mucolytic in cystic fibrosis Journal of the Royal Society of Medicine 2007; 100( supp 47):53-56
Daviskas E, Anderson S.D Hyperosmolar Agents and Clearance of Mucus in the Diseased Airway J Aerosol Medicine Volume 19, Number 1, 2006. 100—109
Daviskas E, Anderson S.D, Gomes K, Briffa P, Cochrane B, Chan H-K, Young I.H, Rubin B.K. Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: Effect on lung function, health status and sputum Respirology, 2005; 10: 46—56
Daviskas E, Turton J.A, Anderson S.D, Young I.H, Lassig A, Charlton B. A placebo controlled trial with inhaled mannitol improves health related quality of life in patients with bronchiectasis Eur Resp J, 2004; 24: 707s ;P4338
Goldman M.D, Daviskas E, Turton J.A, Anderson S.D. Inhaled mannitol improves lung function assessed by forced oscillation in a placebo controlled trial in patients with bronchiectasis Eur Resp J, 2004; 24: 470s-471s ;P2943
Wills P, Greenstone M. Inhaled hyperosmolar agents for bronchiectasis (Cochrane Review) The Cochrane Library, Issue 2, 2004. Chichester, UK: John Wiley & Sons, Ltd.
Daviskas E, Anderson SD, Eberl S, Chan H-K, Young IH, Sealez J.P. Effects of terbutaline in combination with mannitol on mucociliary clearance Eur Resp J, 2002; 20: 1423-1429
Daviskas E, Robinson M, Anderson SD, Bye PTP. Osmotic stimuli increase clearance of mucus in patients with mucociliary dysfunction.    J Aerosol Med 2002; 3: 331-341.
Daviskas E, Anderson SD, Eberl S, Chan H-K, Young IH. The 24-hr effect of mannitol on the clearance of mucus in patients with bronchiectasis.   Chest 2001; 119: 414-421.
Daviskas E, Robinson M, Anderson SD, Bye PTP. [Editor: Salathe M.]  The effect of dry powder mannitol on the clearance of mucus.   In: Cilia and Mucus.Marcel Dekker, New York 2001 pp 361-369.  
Robinson M, Daviskas E, Eberl S, Baker J, Anderson SD, Bye PTP. The effects of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study. Eur Respir J 1999; 14(3):678-685. 
Daviskas E, Anderson SD, Eberl S, Chan H-K, Bautovich G. Inhalation of dry powder mannitol improves mucociliary clearance in patients with bronchiectasis. Amer J Respir Crit Care Med 1999;159:1843-1848.
Daviskas E, Anderson SD, Brannan JD, Chan H-K, Eberl S, Bautovich G. Inhalation of dry powder mannitol increases mucociliary clearance.  

Eur Resp J, 1997; 10: 2449-2454.

Bilton D, Jacques A, Daviskas E, Anderson S, Charlton B. Randomised, Double Blind, Placebo Controlled, Safety and Efficacy Study of Inhaled Dry Powder Mannitol in Bronchiectasis

European Respiratory Society 2008 Annual Congress