Publications & Posters

 Authors Title Reference 

Jarnicki AG, Schilter H, Liu G, Wheeldon K, Essilfie AT, Foot JS, Yow
TT, Jarolimek W, Hansbro PM.

A novel SSAO inhibitor PXS-4728A suppresses inflammation
and fibrosis and improves lung function in experimental chronic obstructive
pulmonary disease

Br J Pharmacol. 2016 Aug 6. doi: 10.1111/bph.13573. [Epub ahead of print]

PMID: 27495192

Link: http://onlinelibrary.wiley.com/doi/10.1111/bph.13573/abstract;jsessionid=231BEAAA122C0AD84A223D01AA644258.f01t02

W Jarolimek, A Buson, L Cao, M Deodhar, A D Findlay, J S Foot,  A Greco, J Moses, H C Schilter, C I Turner, T T Yow, W Zhou

Inhibition of lysyl oxidase like 2 reduces collagen accumulation and collagen cross-links in CCl4-induced liver fibrosis

Abstract and Poster Summary

Foot JS, Deodhar M, Turner CI, Yin P, van Dam EM, Silva DG, Olivieri A, Holt A, McDonald IA. 

The discovery and development of selective 3-fluoro-4-aryloxyallylamine inhibitors of the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1).

Bioorg Med Chem Lett. 22(12):3935-40 (2012)

Barraud N, Buson A, Jarolimek W, Rice SA   

Mannitol Enhances Antibiotic Sensitivity of Persister Bacteria in Pseudomonas aeruginosa Biofilms.

PLoS One 8(12):e84220. (2013)

Link: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0084220 

Foot JS, Yow TT, Schilter H, Buson A, Deodhar M, Findlay AD, Guo L, McDonald IA, Turner CI, Zhou W, Jarolimek W.

PXS-4681A, a Potent and Selective Mechanism-Based Inhibitor of SSAO/VAP-1 with Anti-Inflammatory Effects In Vivo. 

 (2013) J Pharmacol Exp Ther. 347:365-74.

Link: http://jpet.aspetjournals.org/content/347/2/365.long

Wong M, Saad S, Zhang J, Gross S, Jarolimek W, Schilter H, Chen JA, Gill AJ, Pollock CA, Wong MG

Semicarbazide-sensitive amine oxidase (SSAO) inhibition ameliorates kidney fibrosis in a unilateral ureteral obstruction murine model.

 (2014) Am J Phys - Renal Phys. 307: F908-F916

Link: http://ajprenal.physiology.org/content/307/8/F908.long

Schilter HC, Collison A, Russo RC, Foot JS, Yow TT, Vieira AT, Tavares LD, Mattes J, Teixeira MM, Jarolimek W.

Effects of an anti-inflammatory VAP-1/SSAO inhibitor, PXS-4728A, on pulmonary neutrophil migration.

(2015) Respir Res. 20;16:42

Link: http://www.respiratory-research.com/content/16/1/42

Schilter H, Cantemir-Stone CZ, Leksa V, Ohradanova-Repic A, Findlay AD, Deodhar M, Stockinger H, Song X, Molloy M, Marsh CB, Jarolimek W (2015)

The mannose-6-phosphate analogue, PXS64, inhibits fibrosis via TGF-β1 pathway in human lung fibroblasts 

Immunol Lett. 165(2):90-101

Link: http://www.sciencedirect.com/science/article/pii/S0165247815000644