Scientific Publications
Mannitol as a Bronchial Provocation Test
Mannitol as a Mucociliary Clearance Agent
Most of these papers have abstracts that are accessible through PubMed.
Mannitol as a Bronchial Provocation Test:
| Authors | Title | Reference |
|---|---|---|
| Brannan J.D,1, Gulliksson M, Anderson SD, Chew N, Seale JP, Kumlin M | Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing | Eur Respir J 2006; 27: 944—950 |
| Anderson SD | Best indicators of asthma control; Asthma biomarkers including spirometry | AAAI 2006, Session 5533 workshop presentation |
| Stolz D, Gysin C, Miedinger D, Tandjung R, Surber C, Tamm M, Leuppi J | Airway responsiveness to inhaled mannitol is increased in smokers and decreases after short term smoking cessation | CHEST / 128 / 4 / October, 2005 Supplement |
| Brannan JD, Anderson SD, Perry CP, Freed-Martens R, Lassig AR, Charlton B and the Aridol Study Group | The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline | Respiratory Research 2005, 6:144 |
| Carlson KH; taskforce on recognising and diagnosing exercise related asthma, respiratory and allergic disorders in sport.In: Diagnosis and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports. | Evidence based recommendations for the diagnosis of exercise induced asthma in athletes. | Carlsen K-H, Delgado L, Del Giacco S, Eds. Eur Respir Mon: European Respiratory Society, 2005;10(33);Chpt 10 |
| Anderson SD, Bruscasco V, Haahtela T, Popov T.In: Diagnosis and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports. | Criteria for diagnosis of asthma, EIB and AHR for athletes: lessons from the Olympic Games | Carlsen K-H, Delgado L, Del Giacco S,Eds. Eur Respir Mon: European Respiratory Society, 2005; 10(33); Chpt 6 |
| Koskela H, Martens R, Brannan JD, Anderson SD, Leuppi JD, Chan H-K. | Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects | Respirology (2005) 10, 442—448 |
| Anderson S.D, Brannan J.D, Koskela H, Leuppi J.D | Monitoring Airway Hyperresponsiveness: Indirect Stimuli—Exercise, Hypertonic Saline, Mannitol, and AMP | Monitoring Asthma ed. Gibson PG; Taylor and Francis Group, Boca Raton USA |
| Anderson S.D, Brannan J.D, Freed-Martens R.H, and The Aridol Study Group. | Bronchial provocation using inhaled mannitol - a phase 3 trial of paediatric asthmatics and non-asthmatics | ATS 2005 Abstract #955218 |
| Brannan J.D, Anderson S.D, Freed-Martens R.H, and The Aridol Study Group. | Bronchial provocation using inhaled mannitol - a phase 3 trial of adult asthmatics and non-asthmatics | ATS 2005 Abstract #953009 |
| Freed-Martens R, Anderson S.D, Brannan J.D, Aridol study group | Effect of treatment on recovery of FEV1 to baseline after a mannitol challenge: a phase 3 study | Australian New Zealand Soc Resp Sci ASM 2005 Abst. |
| Anderson S.D | Bronchoprovocation Challenges: The How To’s | Session 4701: AAAAI San Antonio Texas 2005 (Pres.) |
| Anderson S.D | Theory and Rationale for bronchial provocation studies in asthma | Session 2714: AAAAI San Antonio Texas 2005 (Pres.) |
| Anderson S.D, Brannan J.D, Koskela H, Freed-Martens R, Leuppi J.D, Holzer K, Lipworth B, Currie K, Sue-Chu M, Perry C.P. | Provoking Dose Of Mannitol To Assess Airway Hyperresponsiveness In Asthma: A Retrospective Analysis | Abstract No: 1460 AAAAI ASM 2005 (Poster) |
| Leuppi J.D, Tandjung R, Anderson S.D, Stolz M.H, Brutsche M.H, Bingisser R, Perruchoud A.P, Surber C, Knoblauch A, Andersson M, Greiff L, Chan H-K, Tamm M | Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept | Pulmonary Pharmacology & Therapeutics 18 (2005) 83—88 |
| Barben J, Riedler J | Measurement of Bronchial Responsiveness in Children | Paed Pulm Function Testing. Prog Respir Res. Basel, Karger, 2005, vol 33, pp 125—136 |
| Tandjung R, Anderson S.D, Brutsche M.H, Bingisser R, Perruchoud A.P, Surber C, Tamm M, Leuppi J.D | Prediction of Treatment-Response to Inhaled Corticosteroids by Mannitol-Challenge Test in COPD | Poster 502 ATS 2004 |
| D. Jaccard-Stolz, M. Tamm, S.D. Anderson, C. Suber, J.D. Leuppi | Bronchial Hyperreactivity to Mannitol before and after Smoking Cessation | Poster K28 ATS 2004 |
| Koskela H.O, Hyv?rinen L, Brannan J.D, Chan H-K, Anderson S.D. | Coughing During Mannitol Challenge Is Associated With Asthma | Chest 2004; 125:1985—1992 |
| Currie G.P, Jackson C.M, Lipworth B.J | Does Bronchial Hyperresponsiveness in Asthma Matter? | J of Asthma Vol. 41, 3, pp. 247—258, 2004 |
| Gulliksson M, Brannan J.D, Anderson S.D, Seale P.J, Delin I, Kumlin M. | Inhibition of the airway response to mannitol with either eformoterol or sodium cromoglycate (SCG) does not alter leukotriene release in asthmatic subjects | Eur Resp J, 2004; 24: 443s ;P2735 |
| Leuppi J.D, Tandjung R, Anderson S.D, Brutsche M.H, Surber C, Bingisser R, Perruchoud A.P, Tamm M | An indirect bronchoprovocation challenge test using the dry powder Mannitol in mild COPD-patients | Poster ERS Vienna 2003 |
| Brannan JD, Anderson SD, Perry CP, Kippelen P, Freed R, Holzer K, Sue-Chu M | Bronchial Provocation Tests using a Dry Powder of Mannitol in Asthmatic and Healthy Subjects with Normal Spirometry | VIIth IOC World Congress on Sports Science Athens, Greece October 2003 |
| Joos G.F (Chairman), O’Connor B (Co-Chairman), Anderson S.D, Chung F, Cockcroft D.W, Dahlén B, DiMaria G, Foresi A, Hargreave F.E, Holgate S.T, Inman M, L?tvall J, Magnussen H, Polosa R, Postma D.S, Riedler J. | ERS Task Force Report: Indirect airway challenges | Eur Respir J 2003; 21: 1050—1068 |
| Barben J, Roberts, Chew N, Carlin J.B, Robertson C.F | Repeatability of Bronchial Responsiveness to Mannitol Dry Powder in Children With Asthma | Pediatric Pulmonology 36:490—494 (2003) |
| Brannan JD | Inhaled Mannitol ; A new Bronchial Provocation Test to assess the presence and severity of asthma. | RT International, Fall 2003: 29-3142. |
| Lee DK, Haggart K, Currie GP, Anderson SD, Lipworth BJ. | The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis. | Br J Clin Pharmacol 2003; 55(6):639-642. |
| Brannan JD, Gulliksson M, Anderson SD, Chew N, Kumlin M. | Evidence of mast cell activation and leukotriene release after mannitol inhalation. | Eur Respir J 2003; 22(3):491-496 |
| Koskela H.O; Hyv?rinen L; Brannan J.D; Chan H.K; Anderson S.D | Responsiveness to Three Bronchial Provocation Tests in Patients With Asthma | Chest 2003; 124:2171—2177 |
| Koskela HO, Hyv?rinen L, Brannan JD, Chan H-K, Anderson SD. | Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. | Chest 2003; 124(4):1341-1349. |
| Currie GP, Haggart K, Brannan JD, Lee DKC, Anderson SD, Lipworth BJ. | Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate. | Allergy 2003 58:762-766 |
| Currie GP, Haggart K, Lee DKC, Fowler SJ, Wilson AM, Brannan JD, Anderson SD, Lipworth BJ. | Effects of mediator antagonism on mannitol and adenosine monophosphate challenges. | Clin Exp Allergy 2003; 33:783-788. |
| Anderson SD, Brannan JD. | Methods for ‘indirect’ challenge tests including exercise, eucapnic voluntary hyperpnea and hypertonic aerosols. | Clin Rev Allergy Immunol 2003; 24: 27-54. |
| Holzer K, Anderson SD, Chan H-K, Douglass J. | Mannitol as a challenge to identify exercise-induced bronchoconstriction in elite athletes. | Am J Respir Crit Care Med 2003; 167: 534-537. |
| Holzer K, Anderson SD, Douglass J. | Exercise in Elite Summer Athletes: challenges for diagnosis. | J Allergy Clin Immunol 2002; 110: 374-380. |
| Anderson SD, Brannan JD, Chan HK. | Use of aerosols for bronchial provocation testing in the laboratory: Where we have been and where we are going. | J Aerosol Med 2002;15(3):313-324. |
| Leuppi JD, Brannan JD, Anderson SD. | Bronchial provocation tests: The rationale for using inhaled mannitol as a test for airway hyperresponsiveness. | Swiss Medical Weekly 2002; 132:151-158. |
| Brannan JD, Koskela H, Anderson SD, Chan H-K. | Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. | Respirology 2002; 7(1):37-44. |
| Leuppi JD. Salome CM, Jenkins CR, Koskela H, Anderson SD, Andersson M, Chan H-K, Woolcock AJ. | Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. | Eur Respir J 2001; 18(3):444-450. |
| Brannan JD, Anderson SD, Gomes K, King GG, Chan H-K, Seale JP. | Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol. | Am J Respir Crit Care Med 2001; 163: 1420-1425. |
| H?gman M, Lúdviksdóttir D,Anderson SD, George S, Hakansson L, Chan HK, Meril?inen,P, Hedenstr?m H. | Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatic and healthy subjects. | Respiration Physiology 2001; 124:141-150. |
| Leuppi JD. Salome CM, Jenkins CR, Anderson SD, Xuan W, Marks GB, Koskela H, Brannan JD, Freed R, Andersson M, Chan H-K, Woolcock AJ. | Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. | Am J Respir Crit Care Med2001; 163:406-412. |
| Koskela H, Di Sciascio M, Anderson SD, Andersson M, Chan H-K, GadallaS, Katelaris C. | Nasal hyperosmolar challenge with a dry powder of mannitol in patients with allergic rhinitis. Evidence for epithelial cell involvement. | Clin Exp Allergy 2000; 30(11):1628-1636. |
| Brannan JD, Anderson SD, Freed R, Leuppi JD, Koskela H, Chan H-K. | Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects. | Am J Respir Crit Care Med 2000; 161; 2096-2099. |
| Subbarao P, Brannan JD, Ho B, Anderson SD, Chan H-K, Coates AL. | Inhaled mannitol identifies methacholine-responsive children with current asthma. | Pediatr Pulmonol 2000; 29:291-298. |
| Brannan JD, Koskela H, Anderson SD, Chew N. | Responsiveness to mannitol in asthmatic subjects with exercise- and hyperventilation-induced asthma. | Am J Respir Crit Care Med, 1998: 158:1120-1126. |
| Anderson SD, Brannan J, Spring J, Spalding N, Rodwell LT, Chan K, Gonda I, Walsh A, Clark AR. | A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. | Am J Respir Crit Care Med 1997; 156: 758-765. |
Mannitol as a Mucociliary Clearance Agent
| Authors | Title | Reference |
|---|---|---|
| Charlton B, Lassig A | Inhaled dry powder mannitol (Bronchitol) improves FEV1 in cystic fibrosis | Abstract TO20 Respirology 2006, 11, (suppl.2): p A11 |
| Daviskas E, Anderson S.D | Hyperosmolar Agents and Clearance of Mucus in the Diseased Airway | J Aerosol Medicine Volume 19, Number 1, 2006. 100—109 |
| Daviskas E, Anderson S.D, Gomes K, Briffa P, Cochrane B, Chan H-K, Young I.H, Rubin B.K. | Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: Effect on lung function, health status and sputum | Respirology, 2005; 10: 46—56 |
| Daviskas E, Turton J.A, Anderson S.D, Young I.H, Lassig A, Charlton B. | A placebo controlled trial with inhaled mannitol improves health related quality of life in patients with bronchiectasis | Eur Resp J, 2004; 24: 707s ;P4338 Presentation also included on CD ROM |
| Goldman M.D, Daviskas E, Turton J.A, Anderson S.D. | Inhaled mannitol improves lung function assessed by forced oscillation in a placebo controlled trial in patients with bronchiectasis | Eur Resp J, 2004; 24: 470s-471s ;P2943 Presentation also included on CD ROM |
| Wills P, Greenstone M. | Inhaled hyperosmolar agents for bronchiectasis (Cochrane Review) | The Cochrane Library, Issue 2, 2004. Chichester, UK: John Wiley & Sons, Ltd. |
| Daviskas E, Anderson SD, Eberl S, Chan H-K, Young IH, Sealez J.P. | Effects of terbutaline in combination with mannitol on mucociliary clearance | Eur Resp J, 2002; 20: 1423-1429 |
| Daviskas E, Robinson M, Anderson SD, Bye PTP. | Osmotic stimuli increase clearance of mucus in patients with mucociliary dysfunction. | J Aerosol Med 2002; 3: 331-341. |
| Daviskas E, Anderson SD, Eberl S, Chan H-K, Young IH. | The 24-hr effect of mannitol on the clearance of mucus in patients with bronchiectasis. | Chest 2001; 119: 414-421. |
| Daviskas E, Robinson M, Anderson SD, Bye PTP. [Editor: Salathe M.] | The effect of dry powder mannitol on the clearance of mucus. | In: Cilia and Mucus.Marcel Dekker, New York 2001 pp 361-369. |
| Robinson M, Daviskas E, Eberl S, Baker J, Anderson SD, Bye PTP. | The effects of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study. | Eur Respir J 1999; 14(3):678-685. |
| Daviskas E, Anderson SD, Eberl S, Chan H-K, Bautovich G. | Inhalation of dry powder mannitol improves mucociliary clearance in patients with bronchiectasis. | Amer J Respir Crit Care Med 1999;159:1843-1848. |
| Daviskas E, Anderson SD, Brannan JD, Chan H-K, Eberl S, Bautovich G. | Inhalation of dry powder mannitol increases mucociliary clearance. | Eur Resp J, 1997; 10: 2449-2454. |
| Bilton D, Jacques A, Daviskas E, Anderson S, Charlton B. | Randomised, Double Blind, Placebo Controlled, Safety and Efficacy Study of Inhaled Dry Powder Mannitol in Bronchiectasis |
European Respiratory Society 2008 Annual Congress |
