Scientific Publications on Aridol 

Most of these papers have abstracts that are accessible through PubMed




Brannan J.D., Bood J.,
Alkhabaz A., Balgoma D.,
Otis J., Delin I., Dahlén B.,
Wheelock C.E., Nair P.,
Dahlén S.-E., O'Byrne P.M.

The effect of omega-3 fatty acids on
bronchial hyperresponsiveness,
sputum eosinophilia, and mast cell mediators in asthma.

Chest 2015 147:2 (397-405).  


Davis B.E., Amakye D.O., Cockcroft D.W. Airway responsiveness to mannitol 24 h after allergen challenge in atopic asthmatics. Allergy: European Journal of Allergy and Clinical Immunology 2015 70:6 (682-688).
Manoharan A., Lipworth B.J., Craig E., Jackson C. The potential role of direct and indirect bronchial challenge testing to identify overtreatment of community managed asthma. Clinical and Experimental Allergy 2014 44:10 (1240-1245).
Leuppi J.D. Bronchoprovocation tests in asthma: Direct versus indirect challenges.

Current Opinion in Pulmonary Medicine 2014 20:1 (31-36).

Davis B.E., Stewart S.L., Martin A.L., Cockcroft D.W. Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma. Respiratory Medicine 2014 108:6 (859-864)
Kim M.-H., Song W.-J., Kim T.-W., Jin H.-J., Sin Y.-S., Ye Y.-M., Kim S.-H., Park H.-W., Lee B.-J., Park H.-S., Yoon H.-J., Choi D.-C., Min K.-U., Cho S.-H. Diagnostic properties of the methacholine and mannitol bronchial challenge tests: A comparison study. Respirology 2014 19:6 (852-856). 
Kalliola S., Malmberg L.P., Kajosaari M., Mattila P.S., Pelkonen A.S., Mäkelä M.J. Assessing direct and indirect airway hyperresponsiveness in children using impulse oscillometry.   Annals of Allergy, Asthma and Immunology 2014 113:2 (166-172).  
Kim C.-H., Woo H., Hyun I.G., Song W.J., Kim C., Choi J.-H., Kim D.-G., Lee M.G., Jung K.-S. Pulmonary function assessment in the early phase of patients with smoke inhalation injury from fire. Journal of Thoracic Disease 2014 6:6 (617-624)
Romberg K.A.M., Berggren A.-C., Bjermer L. Asthma control in patients on fixed dose combination evaluated with mannitol challenge test. Respiratory Medicine 2014 108:2 (264-270). 
Török S.S., Mueller T., Miedinger D., Jochmann A., Zellweger L.J., Sauter S., GollA., Chhajed P.N., Taegtmeyer A.B., Knöpfli B., Leuppi J.D.     An open-label study examining the effect of pharmacological treatment on mannitol- and exercise-induced airway hyperresponsiveness in asthmatic children and adolescents with exercise-induced bronchoconstriction.  BMC Pediatrics 2014 14:1.
Ferraz E., Arruda L.K.P., Bagatin E., Martinez E.Z., Cetlin A.A., Simoneti C.S., Freitas A.S., Martinez J.A.B., Borges M.C., Vianna E.O.   Laboratory animals and respiratory allergies: The prevalence of allergies among laboratory animal workers and the need for prophylaxis. Clinics 2013 68:6 (750-759). 
Cancelliere N., Bobolea I., López-Carrasco V., Barranco P., López-Serrano C., Quirce S. Comparative study of bronchial hyperresponsiveness to methacholine and mannitol in the initial diagnosis of asthma.   Journal of Investigational Allergology and Clinical Immunology 2013 23:5 (361-362).
Amakye D.O., Davis B.E., Martin A.L., Peters G.E., Cockcroft D.W. Refractoriness to inhaled mannitol 3 hours after allergen challenge. Annals of Allergy, Asthma and Immunology 2013 111:3 (182-184). 
Alblooshi A.S., Simpson S.J., Stick S.M., Hall G.L. The safety and feasibility of the inhaled mannitol challenge test in young children. European Respiratory Journal 2013 42:5 (1420-1423).
Porsbjerg C., Sverrild A., Backer V. The usefulness of the mannitol challenge test for asthma. Expert Review of Respiratory Medicine 2013 7:6 (655-663). 
Osthoff M, Michel F, Strupler M, Taegtmeyer AB, Leuppi JD, Perret C. Bronchial hyperersponsiveness testing in athletes of the Swiss Paralympic team. BMC Sports Science, Medicine and Rehabilitation 2013; 5:7 
Barben J, Strippoli MP, Trachsel D, Schiller B, Hammer J, Kuehni CE. Effect of Mannitol Dry Powder Challenge on Exhaled Nitric Oxide in Children. PLoS ONE 2013; Volume 8 (1) e54521.
Williamson PA, Short PM, Vaidyanathan S, Lipworth BJ. Inhaled and systemic corticosteroid response in severe asthma assessed by alveolar nitric oxide: a randomized crossover pilot study of add-on therapy. Br J Clin Pharmacol. 2013 Jan;75(1):93-102. 
Sverrild A, Malinovschi A, Porsbjerg C, Backer V, Alving K. Predicting airway hyperreactivity to mannitol using exhaled nitric oxide in an unselected sample of adolescents and young adults.  Respir Med. 2013 Jan;107(1):150-2. 
Anderson WJ, Short PM, Williamson PA, Lipworth BJ.  Inhaled Corticosteroid Dose Response Using Domiciliary Exhaled Nitric Oxide in Persistent Asthma: The FENOtype trial. Chest 2012; 142: 1553-61.
Farah C.S., King G.G., Brown N.J., Berend N., Salome C.M., Farah C.S., King G.G., Brown N.J., Berend N., Salome C.M., King G.G., Peters M.J. Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration. J Allergy Clin Immunol. 2012 Jul;130(1):61-8. Epub 2012 Mar 27.
Andregnette-Roscigno V., Fernández-Nieto M., Arochena L., García Del Potro M., Aguado E., Sastre J.  Methacholine is more sensitive than mannitol for evaluation of bronchial hyper-responsiveness in youth athletes with exercise-induced bronchoconstriction  Pediatric Allergy and Immunology 2012 23:5: 501-503.
Ulrik C.S., Svenningsen C. High prevalence of asthma in Danish elite canoe- and kayak athletes.  Danish Medical Journal 2012 59(4): 1-5. 
Anderson W.J., McFarlane L.C., Lipworth B.J. Prospective follow-up of novel markers of bone turnover in persistent asthmatics exposed to low and high doses of inhaled ciclesonide over 12 months. Journal of Clinical Endocrinology and Metabolism 2012 97:6 1929-1936. 
Scherr A, Schafroth Torok S, Jochmann A, Miedinger D, Maier S, Taegtmeyer AB, Chhajed PN, Tamm M, Leuppi JD. Response to add-on inhaled corticosteroids in COPD based on airway hyperresponsiveness to mannitol. Chest 2012; 142: 919-26.
Romberg K, Tufvesson E, Bjermer L. Extended diagnostic criteria used for indirect challenge testing in elite asthmatic swimmers. Respir Med. 2012 Jan; 106(1): 15-24.
Ansley L, Kippelen P, Dickinson J, Hull JH.  Misdiagnosis of exercise-induced bronchoconstriction in professional soccer players.  Allergy 2012; 67: 390–395. 
Baraket M, Oliver B, Burgess J, Lim S, King G, Black JL. Is low dose inhaled corticosteroid therapy as effective for inflammation and remodeling in asthma? A randomized, parallel group study.  Respiratory Research 2012, 13:11. 
Lipworth BJ, Short PM, Williamson PA, Clearie KL, Fardon TC, Jackson CM. A randomised primary care trial of Steroid Titration Against Mannitol IN persistent Asthma (STAMINA Trial). Chest. 2012; 141: 607-15.
Anderson WJ, Lipworth BJ. Relationship of Mannitol Challenge to Methacholine Challenge and Inflammatory Markers in Persistent Asthmatics receiving inhaled corticosteroids. Lung 2012 - Manuscript [epub ahead of print]
Decimo F, Capristo C, Amelio R, Maiello N, Capristo AF, Miraglia Del Giudice M. Evaluation of bronchial hyperreactivity with mannitol dry powder challenge test in a paediatric population with intermittent allergic asthma or allergic rhinitis. Int J Immunopathol Pharmacol. 2011 Oct-Dec;24(4):1069-74.
Koskela HO Do we need more than one bronchial provocation test in order to diagnose asthma? Clin & Experimental Allergy 2009; 39: 940-2
Cockcroft D, Davis B. Direct and indirect challenges in the clinical assessment of asthma Ann Allergy Asthma Immunol. 2009 Nov;103(5):363-9. Review
Brannan JD, Porsbjerg C, Anderson SD Inhaled mannitol as a test for bronchial hyperresponsiveness Expert Rev Resp Med 2009; 3(5): 457-468 Review
Porsbjerg C, Backer V, Joos G, et al. Current and future use of the mannitol bronchial challenge in everyday clinical practice Clin Resp J 2009; 3: 189-197
Sverrild A, Porsbjerg C, Thomsen SF, Backer V.J. Diagnostic properties of inhaled mannitol in the diagnosis of asthma: a population study Allergy Clin Immunol. 2009 Nov; 124:928-32
Porsbjerg C, Lund TK, Pedersen L, Backer V. Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO J Asthma. 2009 Aug;46(6):606-12.
Horsman TA, Duke RK, Davenport PW. Airway response to mannitol challenge in asthmatic children using impulse oscillometry. J Asthma. 2009 Aug;46(6):600-3.

Kersten ET, Driessen JM, van der Berg JD, Thio BJ.

Mannitol and exercise challenge test in asthmatic children    Pediatr Pulmonol. 2009 Jul;44(7):655-61.
Cockcroft DW, Davis BE. Diagnostic and therapeutic value of airway challenges in asthma Curr Allergy Asthma Rep. 2009 May;9(3):247-53. Review
Lund TK, Pedersen L, Anderson SD, Sverrild A, Backer V.  Are asthma like symptoms in elite athletes associated with classical features of asthma. Br J Sports Med. 2009 Dec;43(14):1131-5
O'Byrne PM, Gauvreau GM, Brannan JD. Provoked models of asthma: what have we learnt? Clin Exp Allergy. 2009 Feb;39(2):181-92. Review
Anderson SD, Charlton B, Weiler JM, Nichols S, Spector SL, Pearlman DS; A305 Study Group.   Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma Respir Res. 2009 Jan 23;10:4.
Muñoz PA, Gómez FP, Manrique HA, Roca J, Barberà JA, Young IH, Anderson SD, Rodríguez-Roisin R. Pulmonary gas exchangeresponse to exercise- and mannitol-induced bronchoconstriction in mild asthma J Appl Physiol. 2008 Nov;105(5):1477-85. Epub 2008 Aug 28
Rundell KW, Slee JB. Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes J Allergy Clin Immunol. 2008 Aug;122(2):238-46; 247-8. Review.
Anderson SD. Provocation challenges to help diagnose and monitor asthma: exercise, methacholine, adenosine and mannitol. Curr Opin Pulm Med. 2008 Jan;14(1):39-45. Review
Porsbjerg C, Brannan JD, Anderson SD, Backer V. Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients. Clin Exp Allergy. 2008 Jan;38(1):43-50. Epub 2007 Nov 19
Schafroth Török S, Leuppi JD. Bronchial hyperresponsiveness and exhaled nitric oxide in chronic obstructive pulmonary disease Swiss Med Wkly. 2007 Jul 14;137(27-28):385-91. Review.
Miedinger D, Chhajed PN, Tamm M, Stolz D, Surber C, Leuppi JD. Diagnostic tests for asthma in firefighters Chest. 2007 Jun;131(6):1760-7. Epub 2007 Mar 30.
Stolz D, Anderson SD, Gysin C, Miedinger D, Surber C, Tamm M, Leuppi JD. Airway reactivity to inhaled mannitol in cigarette smokers: a longitudinal study Respir Med. 2007 Jul;101(7):1470-6. Epub 2007 Feb 26.
Porsbjerg C, Rasmussen L, Thomsen SF, Brannan JD, Anderson SD, Backer V. Response to mannitol in asymptomatic subjects with airway hyper-responsiveness to methacholine. Clin Exp Allergy. 2007 Jan;37(1):22-8.
Haney S, Hancox RJ. Recovery from bronchoconstriction and bronchodilator tolerance Clin Rev Allergy Immunol. 2006 Oct-Dec;31(2-3):181-96. Review.
Gulliksson M, Palmberg L, Nilsson G, Ahlstedt S, Kumlin M. Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells. Allergy. 2006 Dec;61(12):1473-9.
Menzies D, Nair A, Lipworth BJ. Non-invasive measurement of airway inflammation in asthma J Asthma. 2006 Aug;43(6):407-15. Review.
Brannan J.D,1, Gulliksson M, Anderson SD, Chew N, Seale JP, Kumlin M Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing Eur Respir J 2006; 27: 944—950
Sak I, Kurzawa R, Nowosielska A. Bronchial challenges in asthma control Przegl Lek. 2005;62(12):1488-93. Review. Polish
Anderson SD Best indicators of asthma control; Asthma biomarkers including spirometry AAAI 2006, Session 5533 workshop presentation
Brannan JD, Anderson SD, Perry CP, Freed-Martens R, Lassig AR, Charlton B and the Aridol Study Group The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline Respiratory Research 2005, 6:144
Carlson KH; taskforce on recognising and diagnosing exercise related asthma, respiratory and allergic disorders in sport.In: Diagnosis and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports. Evidence based recommendations for the diagnosis of exercise induced asthma in athletes. Carlsen K-H, Delgado L, Del Giacco S, Eds. Eur Respir Mon: European Respiratory Society, 2005;10(33);Chpt 10
Anderson SD, Bruscasco V, Haahtela T, Popov T.In: Diagnosis and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports. Criteria for diagnosis of asthma, EIB and AHR for athletes: lessons from the Olympic Games Carlsen K-H, Delgado L, Del Giacco S,Eds. Eur Respir Mon: European Respiratory Society, 2005; 10(33); Chpt 6
Koskela H, Martens R, Brannan JD, Anderson SD, Leuppi JD, Chan H-K. Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects Respirology (2005) 10, 442—448
Anderson S.D, Brannan J.D, Koskela H, Leuppi J.D Monitoring Airway Hyperresponsiveness: Indirect Stimuli—Exercise, Hypertonic Saline, Mannitol, and AMP Monitoring Asthma ed. Gibson PG; Taylor and Francis Group, Boca Raton USA
Anderson S.D, Brannan J.D, Freed-Martens R.H, and The Aridol Study Group.  Bronchial provocation using inhaled mannitol - a phase 3 trial of paediatric asthmatics and non-asthmatics ATS 2005 Abstract #955218  
Brannan J.D, Anderson S.D, Freed-Martens R.H, and The Aridol Study Group.   Bronchial provocation using inhaled mannitol - a phase 3 trial of adult asthmatics and non-asthmatics  ATS 2005 Abstract #953009 
Freed-Martens R, Anderson S.D, Brannan J.D, Aridol study group   Effect of treatment on recovery of FEV1 to baseline after a mannitol challenge: a phase 3 study Australian New Zealand Soc Resp Sci ASM 2005 Abst. 
Anderson S.D Bronchoprovocation Challenges: The How To's Session 4701: AAAAI San Antonio Texas 2005 (Pres.)
Anderson S.D Theory and Rationale for bronchial provocation studies in asthma Session 2714: AAAAI San Antonio Texas 2005 (Pres.)
Anderson S.D, Brannan J.D, Koskela H, Freed-Martens R, Leuppi J.D, Holzer K, Lipworth B, Currie K, Sue-Chu M, Perry C.P. Provoking Dose Of Mannitol To Assess Airway Hyperresponsiveness In Asthma: A Retrospective Analysis Abstract No: 1460 AAAAI ASM 2005 (Poster)
Leuppi J.D, Tandjung R, Anderson S.D, Stolz M.H, Brutsche M.H, Bingisser R, Perruchoud A.P, Surber C, Knoblauch A, Andersson M, Greiff L, Chan H-K, Tamm M Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept Pulmonary Pharmacology & Therapeutics 18 (2005) 83—88
Barben J, Riedler J Measurement of Bronchial Responsiveness in Children Paed Pulm Function Testing. Prog Respir Res. Basel, Karger, 2005, vol 33, pp 125—136
Tandjung R, Anderson S.D, Brutsche M.H, Bingisser R, Perruchoud A.P, Surber C, Tamm M, Leuppi J.D Prediction of Treatment-Response to Inhaled Corticosteroids by Mannitol-Challenge Test in COPD Poster 502 ATS 2004
Lee DK Airway hyperresponsiveness to bronchial mannitol: where do we go from here? Chest. 2004 Jul;126(1):318-9; author reply 319-20.
D. Jaccard-Stolz, M. Tamm, S.D. Anderson, C. Suber, J.D. Leuppi Bronchial Hyperreactivity to Mannitol before and after Smoking Cessation Poster K28 ATS 2004
Koskela H.O, Hyvrinen L, Brannan J.D, Chan H-K, Anderson S.D. Coughing During Mannitol Challenge Is Associated With Asthma Chest 2004; 125:1985—1992
Currie G.P, Jackson C.M, Lipworth B.J Does Bronchial Hyperresponsiveness in Asthma Matter? J of Asthma Vol. 41, 3, pp. 247—258, 2004
Gulliksson M, Brannan J.D, Anderson S.D, Seale P.J, Delin I, Kumlin M. Inhibition of the airway response to mannitol with either eformoterol or sodium cromoglycate (SCG) does not alter leukotriene release in asthmatic subjects Eur Resp J, 2004; 24: 443s ;P2735
Leuppi J.D, Tandjung R, Anderson S.D, Brutsche M.H, Surber C, Bingisser R, Perruchoud A.P, Tamm M An indirect bronchoprovocation challenge test using the dry powder Mannitol in mild COPD-patients Poster ERS Vienna 2003
Brannan JD, Anderson SD, Perry CP, Kippelen P, Freed R, Holzer K, Sue-Chu M Bronchial Provocation Tests using a Dry Powder of Mannitol in Asthmatic and Healthy Subjects with Normal Spirometry VIIth IOC World Congress on Sports Science Athens, Greece October 2003
Joos G.F (Chairman), O'Connor B (Co-Chairman), Anderson S.D, Chung F, Cockcroft D.W, Dahlen B, DiMaria G, Foresi A, Hargreave F.E, Holgate S.T, Inman M, L?tvall J, Magnussen H, Polosa R, Postma D.S, Riedler J. ERS Task Force Report: Indirect airway challenges Eur Respir J 2003; 21: 1050—1068
Barben J, Roberts, Chew N, Carlin J.B, Robertson C.F Repeatability of Bronchial Responsiveness to Mannitol Dry Powder in Children With Asthma Pediatric Pulmonology 36:490—494 (2003)
Brannan JD nhaled Mannitol ; A new Bronchial Provocation Test to assess the presence and severity of asthma. RT International, Fall 2003: 29-3142.
Lee DK, Haggart K, Currie GP, Anderson SD, Lipworth BJ. The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis. Br J Clin Pharmacol 2003; 55(6):639-642.
Brannan JD, Gulliksson M, Anderson SD, Chew N, Kumlin M. Evidence of mast cell activation and leukotriene release after mannitol inhalation. Eur Respir J 2003; 22(3):491-496
Koskela H.O; Hyv?rinen L; Brannan J.D; Chan H.K; Anderson S.D Responsiveness to Three Bronchial Provocation Tests in Patients With Asthma Chest 2003; 124:2171—2177
Koskela HO, Hyv?rinen L, Brannan JD, Chan H-K, Anderson SD. Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma. Chest 2003; 124(4):1341-1349.
Currie GP, Haggart K, Brannan JD, Lee DKC, Anderson SD, Lipworth BJ Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate. Allergy 2003 58:762-766
Currie GP, Haggart K, Lee DKC, Fowler SJ, Wilson AM, Brannan JD, Anderson SD, Lipworth BJ. Effects of mediator antagonism on mannitol and adenosine monophosphate challenges. Clin Exp Allergy 2003; 33:783-788.
Anderson SD, Brannan JD. Methods for 'indirect' challenge tests including exercise, eucapnic voluntary hyperpnea and hypertonic aerosols. Clin Rev Allergy Immunol 2003; 24: 27-54.
Holzer K, Anderson SD, Chan H-K, Douglass J. Mannitol as a challenge to identify exercise-induced bronchoconstriction in elite athletes. Am J Respir Crit Care Med 2003; 167: 534-537.
Holzer K, Anderson SD, Douglass J. Exercise in Elite Summer Athletes: challenges for diagnosis. J Allergy Clin Immunol 2002; 110: 374-380.
Anderson SD, Brannan JD, Chan HK. Use of aerosols for bronchial provocation testing in the laboratory: Where we have been and where we are going. J Aerosol Med 2002;15(3):313-324.
Leuppi JD, Brannan JD, Anderson SD. Bronchial provocation tests: The rationale for using inhaled mannitol as a test for airway hyperresponsiveness.  Swiss Medical Weekly 2002; 132:151-158.
 Brannan JD, Koskela H, Anderson SD, Chan H-K. Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects. Respirology 2002; 7(1):37-44.
Leuppi JD. Salome CM, Jenkins CR, Koskela H, Anderson SD, Andersson M, Chan H-K, Woolcock AJ.  Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma. Eur Respir J 2001; 18(3):444-450.
Brannan JD, Anderson SD, Gomes K, King GG, Chan H-K, Seale JP.   Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol. Am J Respir Crit Care Med 2001; 163: 1420-1425.  
Hgman M, Lúdviksdóttir D,Anderson SD, George S, Hakansson L, Chan HK, Meril?inen,P, Hedenstrm H.  Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatic and healthy subjects. Respiration Physiology 2001; 124:141-150. 
Leuppi JD. Salome CM, Jenkins CR, Anderson SD, Xuan W, Marks GB, Koskela H, Brannan JD, Freed R, Andersson M, Chan H-K, Woolcock AJ. Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids. Am J Respir Crit Care Med2001; 163:406-412.
Koskela H, Di Sciascio M, Anderson SD, Andersson M, Chan H-K, GadallaS, Katelaris C. Nasal hyperosmolar challenge with a dry powder of mannitol in patients with allergic rhinitis. Evidence for epithelial cell involvement. Clin Exp Allergy 2000; 30(11):1628-1636.
Brannan JD, Anderson SD, Freed R, Leuppi JD, Koskela H, Chan H-K. Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects. Am J Respir Crit Care Med 2000; 161; 2096-2099.
Subbarao P, Brannan JD, Ho B, Anderson SD, Chan H-K, Coates AL. Inhaled mannitol identifies methacholine-responsive children with current asthma. Pediatr Pulmonol 2000; 29:291-298.
Brannan JD, Koskela H, Anderson SD, Chew N. Responsiveness to mannitol in asthmatic subjects with exercise- and hyperventilation-induced asthma. Am J Respir Crit Care Med, 1998: 158:1120-1126.
Anderson SD, Brannan J, Spring J, Spalding N, Rodwell LT, Chan K, Gonda I, Walsh A, Clark AR. A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol. Am J Respir Crit Care Med 1997; 156: 758-765.