Pharmaxis is an Australian pharmaceutical research company with a portfolio including two respiratory products approved in various world markets and a research pipeline focused on areas of high unmet clinical need in inflammatory and fibrotic diseases.
Established in 1998 and listed on the Australian Securities Exchange in 2003 (symbol PXS) the Company’s head office, manufacturing and research facilities are located in Sydney, Australia.
The Company’s product pipeline is founded on its expertise in the chemistry of amine oxidase inhibitors and includes Semicarbazide-Sensitive Amine Oxidase (SSAO) for Non- Alcoholic Steatohepatitis (NASH) and inflammatory diseases including kidney fibrosis and Chronic Obstructive Pulmonary Disease (COPD), and Lysyl Oxidase Inhibitors (LOX) targeting fibrotic diseases including NASH, pulmonary fibrosis and some cancers.
Pharmaxis’ acknowledged expertise in amine oxide inhibitors has attracted interest from leading pharmaceutical companies looking to make acquisitions or partner in this rapidly expanding area of medical need. In May 2015, Boehringer Ingelheim acquired the Pharmaxis phase 1 investigational drug PXS4728A, to develop it for the treatment of the cardiometabolic liver-related condition NASH.
Pharmaxis manufacturers and exports its approved products from a purpose built manufacturing facility in Sydney.
- Bronchitol®, an inhaled dry powder for the treatment of cystic fibrosis, has been the subject of two large scale global clinical trials conducted by Pharmaxis. The product is approved and marketed in Europe, Russia and Australia and a third large multicentre clinical trial is currently underway aiming to secure approval in the United States. Outside Australia, Pharmaxis partners with a number of specialist companies who have responsibility for their local approvals and ongoing commercialisation of Bronchitol. For more information visit the Bronchitol website.
- Aridol® a lung function test to help diagnose asthma was also the subject of a clinical trial program run by Pharmaxis and is approved and sold in Europe, Australia and Asia. For more information visit the Aridol website.
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